2^nd International conference on
Craniofacial Surgery

We describe a case of left homolateral complete cleft lip/ palate associated with a congenital left maxillary teratoma and left orbital teratoma. The patient required step-by-step reconstruction that first included resection of the 2 teratomas in consideration of cleft lip repair, cleft palate repair, and correction of the left periorbital anomalies, which were performed later. After performing all the necessary procedures, complete resection of the tumors and correction of the anomalies associated with the lip, palate, and left orbit were achieved. The rare occurrence of this type of association and its devastating effect on a patient’s growth, aesthetics, and function of craniofacial elements require careful surgical planning to enable restoration of the anatomy and proper functional development. At follow-up, the patient showed significant improvement in the functional and aesthetic aspects.

Dr. Evirgen has great experience in oral and dental imaging and diagnosis of oral diseases. Oral pathology is Dr. Evirgen’s one of the major areas of interest. She practiced several years in university hospitals and in private practice. Recently she is in faculty stuff of Uşak University Faculty of Dentistry in Turkey.

This study is a retrospective study of patients who underwent surgical odontogenic cyst treatment in Manisa Oral and Dental Health Care Center in Turkey between 2014-2017. A total of 95 patients with complete radiographic and pathologic findings were included in the study. Of the 95 patients, 63 were male and 32 were female. Mean age 38.5, maximum age 84,and minimum age were 13 years. Histopathological evaluation revealed radicular cysts in 73 (76.8%) of 95 patients. Dentigerous cysts in 14 cases (14,7%), keratocysts in 6 cases (6,3%), nasopalatin cyst in 1 case (1,1%) and pseudocyst (1,1%) in 1 case. These findings are mostly consistent with the literature however the distribution of cysts according to age groups differs from the literature.

X Teo is currently a foundation year 1 doctor that is passionate in surgery and in improving the health and wellbeing of her patients. Her consistent engagement in research and quality improvement creates new pathways for improving healthcare. She has also built an interest in cosmetic surgery and minimal wound healing after several years of clinical experience in plastic surgery, otolaryngology, trauma and orthopaedics surgery, vascular surgery, general surgery and general medicine both in hospital and education institutions. She is aspiring to be an ENT surgeon.

Since the discovery of scarless wound healing in human foetuses in 1979 by Rowlatt U., an intensive research has been conducted to unravel the mechanisms underlying it. This study aims to summarise the progression thus far and identify areas which are less understood in order to guide further research. Pubmed was the main database used to source suitable journal articles, using the terms ‘scarless’, ‘wound’ AND ‘healing’ . The inclusion criteria were papers in English, articles done on humans and published in the last 5 years. Exclusion criteria are articles without a full text. Differences between the foetal and adult wound healing are well documented. It is essentially divided into different components, namely the cells, extracellular matrix, growth factors and cytokines. Their respective differences are summarised in the table beside. Another recent discovery was the interaction between MG53, a novel tripartite motif family protein and TGF-B signalling. This interaction promotes scarless wound healing via three mechanisms, a facilitator of rapid injury repair, a mediator of cell migration and a modulator of myofibroblast differentiation. Another comparative study on oral mucosa shows a higher level of expression of fibronectin and chondroitin sulphate, which resembles foetal skin. Another study was done on the human gingiva regarding the function and expression of Connexin (Cxs) 43 in fibroblasts to promote migration and accelerated healing. Lastly, advancement on regenerative medicine have elucidated the contribution of stem cells and growth factors to scarless wound healing. To date, specific cellular differences in foetuses and adults have been identified. The less well understood areas are the cell populations, particularly fibroblasts and transitions from scarring to scarless healing, which can be further looked into. However, regenerative medicine remains the most promising research area thusfar.